- Title
- Are lymphoid follicles important in the pathogenesis of chronic obstructive pulmonary disease?
- Creator
- Hansbro, Phillip M.; Knight, Darryl A.
- Relation
- American Journal of Respiratory and Critical Care Medicine Vol. 188, Issue 3, p. 267-269
- Publisher Link
- http://dx.doi.org/10.1164/rccm.201306-1073ED
- Publisher
- American Thoracic Society
- Resource Type
- journal article
- Date
- 2013
- Description
- Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. It is often induced by cigarette smoking and is characterized by the common pathologies of chronic airway and lung inflammation, mucus hypersecretion, and emphysema that together result in reduced lung function (reviewed in References 2 and 3). The disease course is punctuated by periodic exacerbations that are typically caused by bacterial and viral infections and lead to the progressive deterioration in the patient’s condition. Corticosteroids and other therapies are used to treat the symptoms and exacerbations, but there are no effective treatments the halt the course or reverse the progression of disease. The pathogenesis of COPD is poorly understood, and the interrogation of animal models is likely to lead to a better understanding of pathogenesis and identify new therapeutic avenues. The outcomes of such studies can then be shown to be relevant in samples from patients with COPD.
- Subject
- Chronic obstructive pulmonary disease (COPD); cigarette smoking; lung inflammation; emphysema
- Identifier
- http://hdl.handle.net/1959.13/1056091
- Identifier
- uon:15980
- Identifier
- ISSN:1073-449X
- Language
- eng
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